Middle East respiratory syndrome coronavirus: current situation and travel-associated concerns.
Identifieur interne : 000F83 ( Main/Exploration ); précédent : 000F82; suivant : 000F84Middle East respiratory syndrome coronavirus: current situation and travel-associated concerns.
Auteurs : Jaffar A. Al-Tawfiq ; Ali S. Omrani ; Ziad A. Memish [Oman]Source :
- Frontiers of medicine [ 2095-0225 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- traitement médicamenteux : Infections à coronavirus.
- usage thérapeutique : Antiviraux.
- virologie : Infection croisée.
- épidémiologie : Infections à coronavirus.
- Coronavirus du syndrome respiratoire du Moyen-Orient, Flambées de maladies, Humains, Saisons, Voyage.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Antiviral Agents.
- drug therapy : Coronavirus Infections.
- epidemiology : Coronavirus Infections.
- virology : Cross Infection.
- Disease Outbreaks, Humans, Middle East Respiratory Syndrome Coronavirus, Seasons, Travel.
Abstract
The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 brought back memories of the occurrence of severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002. More than 1500 MERS-CoV cases were recorded in 42 months with a case fatality rate (CFR) of 40%. Meanwhile, 8000 cases of SARS-CoV were confirmed in six months with a CFR of 10%. The clinical presentation of MERS-CoV ranges from mild and non-specific presentation to progressive and severe pneumonia. No predictive signs or symptoms exist to differentiate MERS-CoV from community-acquired pneumonia in hospitalized patients. An apparent heterogeneity was observed in transmission. Most MERS-CoV cases were secondary to large outbreaks in healthcare settings. These cases were secondary to community-acquired cases, which may also cause family outbreaks. Travel-associated MERS infection remains low. However, the virus exhibited a clear tendency to cause large outbreaks outside the Arabian Peninsula as exemplified by the outbreak in the Republic of Korea. In this review, we summarize the current knowledge about MERS-CoV and highlight travel-related issues.
DOI: 10.1007/s11684-016-0446-y
PubMed: 27146399
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 brought back memories of the occurrence of severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002. More than 1500 MERS-CoV cases were recorded in 42 months with a case fatality rate (CFR) of 40%. Meanwhile, 8000 cases of SARS-CoV were confirmed in six months with a CFR of 10%. The clinical presentation of MERS-CoV ranges from mild and non-specific presentation to progressive and severe pneumonia. No predictive signs or symptoms exist to differentiate MERS-CoV from community-acquired pneumonia in hospitalized patients. An apparent heterogeneity was observed in transmission. Most MERS-CoV cases were secondary to large outbreaks in healthcare settings. These cases were secondary to community-acquired cases, which may also cause family outbreaks. Travel-associated MERS infection remains low. However, the virus exhibited a clear tendency to cause large outbreaks outside the Arabian Peninsula as exemplified by the outbreak in the Republic of Korea. In this review, we summarize the current knowledge about MERS-CoV and highlight travel-related issues. </div>
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